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Circulation and Perfusion of Nutrients
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September 10, 2016
6:39 pm
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beingchinmay
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The rate of blood flow through the skin is variable in the human body owing to its primary role in regulating body temperature, which is based on both internal metabolism and external temperature. Because tissues in the skin are fed via the circulation, blood flow becomes an important issue when considering the dose of nutrients. With skin being one of the largest organs in the body and the fact that it is the primary thermoregulatory organ, there are a considerable number of vessels dedicated to perfusion of blood and nutrients. Supplying sufficient nutrients to microorgans such as the hair follicle and sebaceous glands are as important as acquiring the nutrients. The long and winding road to the skin and hair starts with ingestion, digestion, and absorption of nutrients. Hair growth and maintenance are in part linked to vitamin B and folate assimilation through the gastrointestinal tract. Hair growth potential is optimum when specific parameters for biochemical variables such as red blood cell (erythrocyte) generation are in place. These include erythrocyte and serum folate concentrations within the normal range, serum vitamin B12 levels of 300–1,000 ng/l, hemoglobin levels >13.0 g/dl, and serum ferritin concentrations of ³70 ng/ml  One must also consider the skin- and tissue-specific metabolic alterations to the nutrient(s)
supplied along with their half-lives in the surrounding tissues when contemplating delivery of nutrients. Permeation to the appropriate cell types in the follicle and uptake by receptor-specific moieties are essential provided the tissue and its cells are functioning correctly. Finally, degradation of nutrients as well as their metabolic waste products needs to be considered. Other factors affecting nutrient bioavailability are associated with external stresses such as UV radiation and smoke, pharmaceutical drug use, and pathologies associated with the hair shaft and skin

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