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August 26, 2016
Isotretinoin, etretinate, and acitretin were proved to inhibit angiogenesis both in vitro and in vivo (in mice with T47D cell-induced tumors) most probably through RAR-a. Retinoids can stimulate humoral and cellular immunity through enhancing antibody production, increasing blood T-helper cells, and preventing Langerhans cells depletion from epidermis by ultraviolet (UV) light and in vitro increasing cell surface antigens of T and natural killer cells. Antiinflammatory activity of retinoids has also been shown. Inhibition of neutrophil migration in psoriatic skin, inhibiting LTB4-induced migration of neutrophils (topical isotretinoin more than tretinoin or retinoids), and inhibition of nitric oxide and tumor necrosis factor-a (TNFa) production have been reported.
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